THE AIDA STUDY (completed study)

The AIDA consortium is a European Consortium funded by the Seventh Framework Program of the EU to run three randomized clinical trials in different infectious diseases aiming to prove that old and cheap antimicrobials remain equally active to newer and more expensive antimicrobials. The Work Package 2 of the AIDA was run by the HISS through collaboration with Micron Research Ltd.

Study title: “A prospective, open label, randomized controlled clinical trial, with pharmacokinetic-pharmacodynamic validation, to compare antimicrobial treatment with oral minocycline plus rifampicin to treatment with oral linezolid for complicated skin and skin structure infections (cSSSI) caused by methicillin-resistant Staphylococcus aureus (MRSA)”.

EudraCT number: 2014-001276-56
National Organization for Medicines Approval: IS-83/14
National Ethics Committee Approval: 87/14
Duration: November 2014 and December 2016
Study phase: IV
Number of Study sites: 17
Total number of enrolled patients: 122

Site
Hospital
PI
Enrolled pts
Dpt of Internal Medicine
Argos Hospital
G. Mavras & I. Kritselis
14
1st Dpt of Internal Medicine
“G.Gennimatas” General Hospital
P. Gargalianos
2
Dpt of Plastic Surgery
“G.Gennimatas” General Hospital
D. Tsoutsos
6
1st Dpt of Internal Medicine
“Evangelismos” General Hospital
E. Kokkinakis
0
3rd Dpt of Internal Medicine
“Evangelismos” General Hospital
T. Kontopoulou
48
1st Dpt of Internal Medicine
Thriasion General Hospital
S. Symbardi
10
2nd Dpt of Internal Medicine
Thriasion General Hospital
Z. Alexiou
11
2nd Dpt of Internal Medicine
Ippokration General Hospital
H. Sambatakou
2
2nd Department of Surgery
Ippokration General Hospital
K. Toutouzas
6
Dpt of Internal Medicine
University General Hospital of Patra
C. Gogos
3
2nd Dpt of Internal Medicine
Sismanoglion General Hospital
E. Dimitrellos
5
1st Dpt of Internal Medicine
University General Hospital of Thessaloniki AHEPA
S. Metallidis
0
2nd Dpt of Surgery
G. Gennimatas General Hospital of Thessaloniki
I. Koutelidakis
7
Dpt of Internal Medicine
KAT General Hospital
M. Lelekis
0
3rd Dpt of Internal Medicine
Korgialenio-Benakeion General Hospital
M. Lazanas
0
3rd Dpt of Internal Medicine
Sotiria General Hospital of Chest Diseases
K.Syrigos
0
Dpt of Internal Medicine
Lamia General Hospital
M.Bristianou
7