ACTIVATE is a randomized clinical trial aiming to investigate if the developing concept of trained immunity i.e. the memory of the innate immune system coming after vaccination exists in humans and may lead to protection from infections.

Study title: “A randomized Clinical Trial for enhanced trained Immune responses through bacillus calmette-guérin VAccination to prevenT infections of the Elderly” NCT03296423
EudraCT number 2017-000596-87
National Ethics Committee approval: 27/17
Study phase: II
Study sites: one site in Greece
Target of enrolment: 200 patients
Starting month: October 2017
Anticipated end month: December 2019